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Image Search Results
Journal: Cancer Research
Article Title: Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation
doi: 10.1158/0008-5472.can-12-1451
Figure Lengend Snippet: Figure 5. The reprogramming potentials of mutant p53 are allele specific. p53 missense mutant cells (10)3.143, (10)3.175, (10)3.273, (10)3.248, (10).281, and control p53 null cell (10)3 were reprogrammed by either 4 factors (Oct4, Sox2, Klf4, and c-Myc) cocktail or 3 factors (Oct4, Sox2, and Klf4) cocktail. A, when reprogrammed by 4 factors, most of the p53 missense mutation exhibited significant lower efficiency except (10) 3.273. B, when reprogrammed by 3 factors, 3 mutations, (10)3.143 (indicated by ), (10)3.175 (indicated by ), and (10)3.273 exhibited higher efficiencies than (10)3 p53 null cells. No iPSC colonies can be detected from (10)3.248 and (10)3.281 cells by 3 factors cocktail.
Article Snippet: Retroviral vectors encoding each of the mouse genes OCT4, SOX2, C-MYC, and
Techniques: Mutagenesis, Control